Mechanisms of Repression by Polycomb Proteins
KeywordsPolycomb, Chromatin, Biochemistry, Methylation, Cancer
Polycomb Group Proteins maintain gene silencing throughout development and adulthood by interfering with chromatin structure. Depending on the cell type, distinct sets of genes get targeted by these proteins. How is this cell specificity established and maintained, what happen when the machinery gets awry are the main questions that we are investigating.
Polycomb Group (PcG) proteins maintain the pattern of gene expression of different cells set early during development by regulating chromatin structure. Consequently interfering with PcG proteins expression affects various biological processes such as differentiation, proliferation or maintenance of pluripotency. In addition, PcG genes are found deregulated in various pathologies including cancer.