KeywordsStem cells, Proliferation, Differentiation, Development, Cancer
We are using the stem cells in the adult intestine of Drosophila to uncover general mechanisms controlling stem cells and their differentiated daughter progeny. Our work takes advantage of the sophisticated genetic tools available in Drosophila and high-resolution confocal imaging to investigate the cell biology of the intestine.
Stem cells are essential for development and continued maintenance of tissues and organs. They are characterized by their ability to self-renew as well as to produce differentiated progeny. Understanding the dual capacity of self-renewal and differentiation is an important aim of developmental biology, regenerative medicine, and also has implications for cancer biology.
Understanding cell fate specification