Epigenetic decisions and reproduction in mammals
KeywordsEpigenetics, DNA methylation, germ line, mouse development, reproduction, genomic imprinting
Our research is centered on the window of conception in mammals. We are interested in the epigenetic information, beyond the genetic material, that prepares the egg and the sperm for the process of fertilization and how this information impacts immediately on the embryo but also, on a longer term, on the adult individual and eventually, on the next generations.
The process of germ line differentiation allows the production of mature gametes that carry both genetic and epigenetic information.
Epigenetic remodelling of the germ line has a dual effect, creating a state of extreme differentiation that allows the egg and the sperm to perform fertilization, while maintaining pluripotent properties necessary to support the development of a new individual.